Skin Inflammation and Barrier Repair: The Role of Omega-3 and Resolvins in Atopic Skin
Omega-3 fatty acids and resolvins play a key role in controlling skin inflammation and restoring the skin barrier in people with atopic skin.
Discover how these molecules work — and how Xantopix AD Cream by Synchroline supports the natural balance of sensitive, inflamed skin.
Atopic Skin and Inflammation: Understanding the Connection
Atopic dermatitis is a common chronic inflammatory skin condition that affects 10–20% of children and 2–5% of adults worldwide. It is characterized by inflammation, persistent dryness, and intense itching, all linked to a weakened skin barrier. In recent years, dermatological research has highlighted the crucial role of certain natural inflammation mediators, such as Omega-3 fatty acids and resolvins, in maintaining the health and functionality of atopic skin.
The skin barrier; your first line of defense
The skin barrier is composed of lipids, proteins, and cells that work together to prevent water loss and protect the body from external aggressors.
In atopic skin, this barrier becomes weakened:
- • The skin loses hydration more easily;
- • Production of protective lipids (ceramides, fatty acids, cholesterol) decreases;
- • Irritants and allergens penetrate more easily.
This creates a vicious cycle: cryness → inflammation → itching → more barrier damage.
Skin inflammation: what happens in atopic dermatitis
Inflammation in atopic dermatitis is a complex process involving:
- • an overactive immune response;
- • release of pro-inflammatory cytokines;
- • impaired resolution of inflammation.
Under normal conditions, the body naturally produces molecules called resolvins, derived from Omega-3 fatty acids, which help “switch off” inflammation once it has served its purpose.
However, in atopic skin, this resolution system may be compromised, leading to prolonged inflammation and discomfort.
Omega-3 and Resolvins: natural allies against inflammation
Omega-3 fatty acids (such as EPA and DHA) are essential nutrients found in oily fish, flaxseeds, and hemp oil. In the body, they are converted into resolvins — bioactive molecules that:
- • regulate immune cell activity, preventing excessive inflammatory responses;
- • support tissue repair and restoration of the skin barrier;
- • reduce redness, itching, and dryness;
- • stimulate the production of healthy skin lipids, keeping the skin soft and protected.
In dermatology, these are known as “pro-resolving mediators”: rather than suppressing inflammation, they restore physiological balance, promoting the skin’s natural healing processes.
How to strengthen the skin barrier in atopic skin
To help atopic skin regain balance and comfort, it is essential to:
- 1. moisturize daily with emollients rich in physiological lipids;
- 2. reduce dryness by using gentle cleansers free of harsh surfactants;
- 3.Support natural anti-inflammatory processes with functional ingredients derived from Omega-3 and resolvins;
- 4.protect the skin from external irritants and avoid over-cleansing.
The Synchroline solution: Xantopix AD and the power of Resolvins
Xantopix AD Cream is formulated to meet the specific needs of dry, inflamed, and atopic skin, with an innovative dermocosmetic approach inspired by the body’s natural mechanisms for resolving inflammation. Thanks to its content of stearidonic acid (an Omega-3 fatty acid) — a precursor of EPA, from which resolvins are derived — combined with xylitol, MSM, and ceramides, Xantopix AD Cream helps to:
- • modulate skin inflammation, reducing redness and itching;
- • reinforce the lipid barrier and improve the skin’s protective function;
- • restore comfort, elasticity, and hydration;
- • Normalize the skin microbiota, supporting overall balance and resilience.
Omega-3 fatty acids and resolvins represent a new frontier in the management of atopic skin.
They work in harmony with the skin’s biological processes to reduce inflammation, protect the barrier, and promote healthier, more comfortable skin.
With Xantopix AD Cream, Synchroline translates scientific research into functional dermocosmetics that provide relief and protection — even for the most sensitive skin.
How to use XANTOPIX AD Cream
Use regularly, preferably two to three times a day for optimal results.
